Sentinel lymph node detection rates using indocyanine green in women with early-stage cervical cancer
Identifieur interne : 000B24 ( Main/Exploration ); précédent : 000B23; suivant : 000B25Sentinel lymph node detection rates using indocyanine green in women with early-stage cervical cancer
Auteurs : Anna L. Beavis [États-Unis] ; Sergio Salazar-Marioni [États-Unis, Mexique] ; Abdulrahman K. Sinno [États-Unis] ; Rebecca L. Stone [États-Unis] ; Amanda N. Fader [États-Unis] ; Antonio Santillan-Gomez [États-Unis] ; Edward J. Tanner [États-Unis]Source :
- Gynecologic oncology [ 0090-8258 ] ; 2016.
Abstract
Our study objective was to determine feasibility and mapping rates using indocyanine green (ICG) for sentinel lymph node (SLN) mapping in early-stage cervical cancer.
We performed a retrospective review of all women who underwent SLN mapping with ICG during primary surgical management of early-stage cervical cancer by robotic-assisted radical hysterectomy (RA-RH) or fertility-sparing surgery. Patients were treated at two high-volume centers from 10/2012 to 02/2016. Completion pelvic lymphadenectomy was performed after SLN biopsy; additionally, removal of clinically enlarged/suspicious nodes was part of the SLN treatment algorithm.
Thirty women with a median age of 42.5 and BMI of 26.5 were included. Most (90%) had stage IB disease, and 67% had squamous histology. RA-RH was performed in 86.7% of cases. One patient underwent fertility-sparing surgery. Median cervical tumor size was 2.0 cm. At least one SLN was detected in all cases (100%), with bilateral mapping achieved in 87%. SLN detection was not impacted by tumor size and was most commonly identified in the hypogastric (40.3%), obturator (26.0%), and external iliac (20.8%) regions. Five cases of lymphatic metastasis were identified (16.7%): three in clinically enlarged SLNs, one in a clinically enlarged non-SLN, and one case with cytokeratin positive cells in an SLN. All metastatic disease would have been detected even if full lymphadenectomy had been omitted from our treatment algorithm,
SLN mapping with ICG is feasible and results in high detection rates in women with early-stage cervical cancer. Prospective studies are needed to determine if SLN mapping can replace lymphadenectomy in this setting.
Url:
DOI: 10.1016/j.ygyno.2016.08.236
PubMed: 27526991
PubMed Central: 5576021
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003321
- to stream Pmc, to step Curation: 003320
- to stream Pmc, to step Checkpoint: 000605
- to stream Ncbi, to step Merge: 008694
- to stream Ncbi, to step Curation: 008694
- to stream Ncbi, to step Checkpoint: 008694
- to stream Main, to step Merge: 000B25
- to stream Main, to step Curation: 000B24
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sentinel lymph node detection rates using indocyanine green in women with early-stage cervical cancer</title>
<author><name sortKey="Beavis, Anna L" sort="Beavis, Anna L" uniqKey="Beavis A" first="Anna L." last="Beavis">Anna L. Beavis</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salazar Marioni, Sergio" sort="Salazar Marioni, Sergio" uniqKey="Salazar Marioni S" first="Sergio" last="Salazar-Marioni">Sergio Salazar-Marioni</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Texas Oncology, San Antonio, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Texas Oncology, San Antonio, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Monterrey, San Pedro Garza Garcia, Mexico</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>University of Monterrey, San Pedro Garza Garcia</wicri:regionArea>
<wicri:noRegion>San Pedro Garza Garcia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sinno, Abdulrahman K" sort="Sinno, Abdulrahman K" uniqKey="Sinno A" first="Abdulrahman K." last="Sinno">Abdulrahman K. Sinno</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stone, Rebecca L" sort="Stone, Rebecca L" uniqKey="Stone R" first="Rebecca L." last="Stone">Rebecca L. Stone</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fader, Amanda N" sort="Fader, Amanda N" uniqKey="Fader A" first="Amanda N." last="Fader">Amanda N. Fader</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Santillan Gomez, Antonio" sort="Santillan Gomez, Antonio" uniqKey="Santillan Gomez A" first="Antonio" last="Santillan-Gomez">Antonio Santillan-Gomez</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Texas Oncology, San Antonio, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Texas Oncology, San Antonio, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tanner, Edward J" sort="Tanner, Edward J" uniqKey="Tanner E" first="Edward J." last="Tanner">Edward J. Tanner</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27526991</idno>
<idno type="pmc">5576021</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576021</idno>
<idno type="RBID">PMC:5576021</idno>
<idno type="doi">10.1016/j.ygyno.2016.08.236</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">003321</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003321</idno>
<idno type="wicri:Area/Pmc/Curation">003320</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003320</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000605</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000605</idno>
<idno type="wicri:Area/Ncbi/Merge">008694</idno>
<idno type="wicri:Area/Ncbi/Curation">008694</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">008694</idno>
<idno type="wicri:doubleKey">0090-8258:2016:Beavis A:sentinel:lymph:node</idno>
<idno type="wicri:Area/Main/Merge">000B25</idno>
<idno type="wicri:Area/Main/Curation">000B24</idno>
<idno type="wicri:Area/Main/Exploration">000B24</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sentinel lymph node detection rates using indocyanine green in women with early-stage cervical cancer</title>
<author><name sortKey="Beavis, Anna L" sort="Beavis, Anna L" uniqKey="Beavis A" first="Anna L." last="Beavis">Anna L. Beavis</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salazar Marioni, Sergio" sort="Salazar Marioni, Sergio" uniqKey="Salazar Marioni S" first="Sergio" last="Salazar-Marioni">Sergio Salazar-Marioni</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Texas Oncology, San Antonio, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Texas Oncology, San Antonio, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">University of Monterrey, San Pedro Garza Garcia, Mexico</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>University of Monterrey, San Pedro Garza Garcia</wicri:regionArea>
<wicri:noRegion>San Pedro Garza Garcia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sinno, Abdulrahman K" sort="Sinno, Abdulrahman K" uniqKey="Sinno A" first="Abdulrahman K." last="Sinno">Abdulrahman K. Sinno</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stone, Rebecca L" sort="Stone, Rebecca L" uniqKey="Stone R" first="Rebecca L." last="Stone">Rebecca L. Stone</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fader, Amanda N" sort="Fader, Amanda N" uniqKey="Fader A" first="Amanda N." last="Fader">Amanda N. Fader</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Santillan Gomez, Antonio" sort="Santillan Gomez, Antonio" uniqKey="Santillan Gomez A" first="Antonio" last="Santillan-Gomez">Antonio Santillan-Gomez</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Texas Oncology, San Antonio, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Texas Oncology, San Antonio, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tanner, Edward J" sort="Tanner, Edward J" uniqKey="Tanner E" first="Edward J." last="Tanner">Edward J. Tanner</name>
<affiliation wicri:level="1"><nlm:aff id="A1">The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD</wicri:regionArea>
<wicri:noRegion>MD</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Gynecologic oncology</title>
<idno type="ISSN">0090-8258</idno>
<idno type="eISSN">1095-6859</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Our study objective was to determine feasibility and mapping rates using indocyanine green (ICG) for sentinel lymph node (SLN) mapping in early-stage cervical cancer.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We performed a retrospective review of all women who underwent SLN mapping with ICG during primary surgical management of early-stage cervical cancer by robotic-assisted radical hysterectomy (RA-RH) or fertility-sparing surgery. Patients were treated at two high-volume centers from 10/2012 to 02/2016. Completion pelvic lymphadenectomy was performed after SLN biopsy; additionally, removal of clinically enlarged/suspicious nodes was part of the SLN treatment algorithm.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Thirty women with a median age of 42.5 and BMI of 26.5 were included. Most (90%) had stage IB disease, and 67% had squamous histology. RA-RH was performed in 86.7% of cases. One patient underwent fertility-sparing surgery. Median cervical tumor size was 2.0 cm. At least one SLN was detected in all cases (100%), with bilateral mapping achieved in 87%. SLN detection was not impacted by tumor size and was most commonly identified in the hypogastric (40.3%), obturator (26.0%), and external iliac (20.8%) regions. Five cases of lymphatic metastasis were identified (16.7%): three in clinically enlarged SLNs, one in a clinically enlarged non-SLN, and one case with cytokeratin positive cells in an SLN. All metastatic disease would have been detected even if full lymphadenectomy had been omitted from our treatment algorithm,</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">SLN mapping with ICG is feasible and results in high detection rates in women with early-stage cervical cancer. Prospective studies are needed to determine if SLN mapping can replace lymphadenectomy in this setting.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Mexique</li>
<li>États-Unis</li>
</country>
<region><li>Texas</li>
</region>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Beavis, Anna L" sort="Beavis, Anna L" uniqKey="Beavis A" first="Anna L." last="Beavis">Anna L. Beavis</name>
</noRegion>
<name sortKey="Fader, Amanda N" sort="Fader, Amanda N" uniqKey="Fader A" first="Amanda N." last="Fader">Amanda N. Fader</name>
<name sortKey="Salazar Marioni, Sergio" sort="Salazar Marioni, Sergio" uniqKey="Salazar Marioni S" first="Sergio" last="Salazar-Marioni">Sergio Salazar-Marioni</name>
<name sortKey="Santillan Gomez, Antonio" sort="Santillan Gomez, Antonio" uniqKey="Santillan Gomez A" first="Antonio" last="Santillan-Gomez">Antonio Santillan-Gomez</name>
<name sortKey="Santillan Gomez, Antonio" sort="Santillan Gomez, Antonio" uniqKey="Santillan Gomez A" first="Antonio" last="Santillan-Gomez">Antonio Santillan-Gomez</name>
<name sortKey="Sinno, Abdulrahman K" sort="Sinno, Abdulrahman K" uniqKey="Sinno A" first="Abdulrahman K." last="Sinno">Abdulrahman K. Sinno</name>
<name sortKey="Stone, Rebecca L" sort="Stone, Rebecca L" uniqKey="Stone R" first="Rebecca L." last="Stone">Rebecca L. Stone</name>
<name sortKey="Tanner, Edward J" sort="Tanner, Edward J" uniqKey="Tanner E" first="Edward J." last="Tanner">Edward J. Tanner</name>
</country>
<country name="Mexique"><noRegion><name sortKey="Salazar Marioni, Sergio" sort="Salazar Marioni, Sergio" uniqKey="Salazar Marioni S" first="Sergio" last="Salazar-Marioni">Sergio Salazar-Marioni</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B24 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B24 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:5576021 |texte= Sentinel lymph node detection rates using indocyanine green in women with early-stage cervical cancer }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27526991" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |